Harnessing Optimal Immunity for Protection From Life-Threatening Respiratory Virus Infections

IFN-gene signatures in B cells following influenza A and B virus infection and influenza vaccination

W Zhang, EK Allen, S Li, I Tarasova, R Farrukee, L Kedzierski, B Gilbertson, HA McQuilten, JR Habel, LF Allen, S Rockman, SL Londrigan, SJ Kent, AK Wheatley, JA Trubiano, TC Kotsimbos, AC Cheng, J Schroeder, JC Crawford, PG Thomas

2026-04-15

Influenza viruses continue to cause a substantial global disease burden. Despite influenza vaccination, some individuals succumb t..

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells

X Jia, IJH Foo, HA McQuilten, JC Crawford, AF Cabug, D Gebregzabher, J Chou, RC Mettelman, T Novak, LA Van de Velde, RS Thwaites, AG Randolph, PG Thomas, J Xu, Z Wang, K Kedzierska, L Kedzierski, BY Chua

2026-03-01

Objectives: Our previous study in hospitalised patients infected with avian A(H7N9) influenza virus identified CD84 amongst severa..

Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8 resident memory T cells

THO Nguyen, HA McQuilten, A Pizzolla, S Sant, KL Harland, J Braverman, K Kedzierska, LM Wakim

2026-01-01

Tissue-resident memory (Trm) CD8⁺ T cells in the upper and lower respiratory tract play an instrumental role in combatt..

High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

AF Cabug, JC Crawford, HA McQuilten, IJH Foo, LF Allen, D Gebregzabher, RC Mettelman, T Novak, J Chou, LC Rowntree, RR Hagen, AJ Thomson, GE Martin, B Gilbertson, MNT Souter, F James, E Goodall, S Rizzetto, T Flerlage, X Jia

2025-12-01

Hyperactivated immunity underpins severe outcomes of respiratory viral infections, yet specific immune perturbations are ill-defin..

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

L Dalit, CW Tan, AA Sheikh, R Munnings, LJ Howson, C Alvarado, T Hussain, A Zaini, L Cooper, A Kirn, L Hailes, A Nguyen, BE Williams, MZM Zheng, CE van de Sandt, LK Mackay, KL Flanagan, K Kedzierska, N Harris, JA Juno

2025-10-01

CD4⁺ T follicular helper (T<inf>FH</inf>) cells support tailored B cell responses against multiple classes of pathogens..

Immune responses underpinning acute co-infections with unrelated viruses: Timing and location matter

IJH Foo, L Kedzierski, K Kedzierska

2025-09-01

Immunity to viral infections is generally studied in isolation by measuring immune responses towards a single virus. However, conc..

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8 T cell pools across the human lifespan

T Menon, HA McQuilten, J Samir, THO Nguyen, R Lim, J Kaur, S Rizzetto, A Eltahla, PG Thomas, M Lappas, J Rossjohn, S Gras, J Crowe, KL Flanagan, F Luciani, PC Doherty, CE van de Sandt, K Kedzierska

2025-07-29

Central memory CD8⁺ T cells (T<inf>cm</inf>) represent the prominent memory T cell subset in human blood, yet the persi..

Gradual changes within long-lived influenza virus-specific CD8 T cells are associated with the loss of public TCR clonotypes in older adults

CE van de Sandt, HA McQuilten, M Aban, THO Nguyen, SA Valkenburg, EJ Grant, S Sant, J Rossjohn, S Gras, J Crowe, K Kedzierska

2025-05-01

Background: Susceptibility to life-threatening influenza increases with age, partly due to declining immunity. Frequency, phenotyp..